Autism News

Maternal Metabolic Conditions and Risk for Autism and other Neurodevelopmental Disorders

Source: 
Pediatrics
Date Published: 
May, 2012
Abstract: 

Maternal metabolic conditions may be broadly associated with neurodevelopmental problems in children. With obesity rising steadily, these results appear to raise serious public health concerns.

Rate of De Novo Mutations and the Importance of Father’s Age to Disease Risk

Source: 
Nature
Date Published: 
August 23, 2012
Abstract: 

The diversity in mutation rate of SNP's is dominated by the age of the father at conception of the child. The effect is an increase of about two mutations per year.

A Novel Approach of Homozygous Haplotype Sharing Identifies Candidate Genes in Autism Spectrum Disorder

Source: 
Human Genetics
Date Published: 
April, 2012
Abstract: 

A large scale analysis identifies candidate genes which may contain low-frequency recessive variations contributing to ASD

The Genetic Variability and Commonality of Neurodevelopmental Disease

Source: 
American Journal of Medical Genetics; Part C, Seminars in Medical Genetics
Date Published: 
May 15, 2012
Abstract: 

Copy Number Variations suggest that the distinction between milder neuropsychiatric conditions from those of severe developmental impairment may be a consequence of increased mutational burden affecting more genes

A Common X-linked Inborn Error of Carnitine Biosynthesis May be a Risk Factor for Nondysmorphic Autism.

Source: 
Proceedings of the National Academy of Sciences of the United States of America
Date Published: 
May 22, 2012
Abstract: 

These data suggest that dysregulation of carnitine metabolism may be important in nondysmorphic autism; that abnormalities of carnitine intake, loss, transport, or synthesis may be important in a larger fraction of nondysmorphic autism cases; and that the carnitine pathway may provide a novel target for therapy or prevention of autism.

Day and Nighttime Excretion of 6-sulphatoxymelatonin in Adolescents and Young Adults with Autistic Disorder

Source: 
Psychoneuroendocrinology
Date Published: 
December, 2012
Abstract: 

Low melatonin excretion was observed in autism, both at daytime, nighttime, and during 24h collection. Nocturnal excretion of melatonin was negatively correlated with autism severity in the overall level of verbal language, imitative social play, and repetitive use of objects.

Sleep Disruption as a Correlate to Cognitive and Adaptive Behavior Problems in Autism Spectrum Disorders

Source: 
Research in Developmental Disabilities
Date Published: 
October, 2012
Abstract: 

The results indicate that quality of sleep, especially sleep duration, may be related to problems with day-time cognitive and adaptive functioning in children with autism and PDD-NOS.

Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism

Source: 
Science Translational Medicine
Date Published: 
April 25, 2012
Abstract: 

Using a mouse model with behaviors relevant to the three diagnostic behavioral symptoms of autism, researchers used a genetic approach to reduce repetitive behaviors and partially reverse the striking lack of sociability in these mice.

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-dependent Manner

Source: 
Neuron
Date Published: 
May 24, 2012
Abstract: 

This article demonstrated that microglia, immune cells of the brain and spinal cord, have a role in reshaping the connections between cells during postnatal development.

Decreased Amino Acid L-Tryptophan Metabolism In Patients With ASD

Source: 
Molecular Autism
Date Published: 
June 4, 2013
Abstract: 

The study found that individuals with ASD had significantly decreased metabolism of the amino acid L-Tryptophan compared to their control group and individuals with other neurodevelopmental disorders. This amino acid could be used as a potential indicator for a simple, early blood test for autism.