Autism Research

Patterns and rates of exonic de novo mutations in autism spectrum disorders.

Source: 
PubMed
Date Published: 
April 4, 2012
Abstract: 

Control study provide strong evidence in favour of CHD8 and KATNAL2 as genuine autism risk factors.

Levels of select PCB and PBDE congeners in human postmortem brain reveal possible environmental involvement in 15q11-q13 duplication autism spectrum disorder.

Source: 
PubMed
Date Published: 
October 2012
Abstract: 

Results demonstrate a novel paradigm by which specific POPs may predispose to genetic copy number variation of 15q11-q13.

CNVs: harbingers of a rare variant revolution in psychiatric genetics.

Source: 
PubMed
Date Published: 
March 16, 2012
Abstract: 

CNV studies reflects the nature of rare alleles in general and will serve as a guide as we move forward into a new era of whole-genome sequencing.

Migration and autism spectrum disorder: population-based study.

Source: 
PubMed
Date Published: 
August 2012
Abstract: 

Children of migrant parents may be at greater risk of low-functioning autism spectrum disorder, but lower risk of high-functioning autism spectrum disorder.

A Research Strategy to Discover the Environmental Causes of Autism and Neurodevelopmental Disabilities

Source: 
Environmental Health Perspectives
Date Published: 
July 2, 2012
Abstract: 

It is intended to focus research in environmental causation of NDDs on a short list of chemicals where concentrated study has high potential to generate actionable findings in the near future. Its ultimate purpose is to catalyze new evidence-based programs for prevention of disease in America’s children.

Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders.

Source: 
PubMed
Date Published: 
May 2012
Abstract: 

Maternal MCs may be broadly associated with neurodevelopmental problems in children. With obesity rising steadily, these results appear to raise serious public health concerns.

Rate of de novo mutations and the importance of father's age to disease risk.

Source: 
PubMed
Date Published: 
August 23, 2012
Abstract: 

These observations shed light on the importance of the father's age on the risk of diseases such as schizophrenia and autism.

De Novo Gene Disruptions in Children on the Autistic Spectrum.

Source: 
Neuron
Date Published: 
April 26, 2012
Abstract: 

FMRP-associated genes are under greater purifying selection than the remainder of genes and suggest they are especially dosage-sensitive targets of cognitive disorders.

A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.

Source: 
PubMed
Date Published: 
April 2012
Abstract: 

Findings highlight the applicability of HH mapping in complex disorders such as ASD and offer an alternative approach to the analysis of genome-wide association data.

Genetic Architecture in Autism Spectrum Disorder.

Source: 
Current Opinion in Genetics and Development
Date Published: 
June 2012
Abstract: 

Biological pathways revealed by the deeper list of ASD genes should narrow the targets for therapeutic intervention.