Autism Research

A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.

Source: 
PubMed
Date Published: 
April 2012
Abstract: 

Findings highlight the applicability of HH mapping in complex disorders such as ASD and offer an alternative approach to the analysis of genome-wide association data.

Genetic Architecture in Autism Spectrum Disorder.

Source: 
Current Opinion in Genetics and Development
Date Published: 
June 2012
Abstract: 

Biological pathways revealed by the deeper list of ASD genes should narrow the targets for therapeutic intervention.

The genetic variability and commonality of neurodevelopmental disease.

Source: 
PubMed
Date Published: 
May 15, 2010
Abstract: 

Recent genetic studies have revealed some common themes: considerable locus heterogeneity, variable expressivity for the same mutation, and a role for multiple disruptive events in the same individual affecting genes in common pathways.

A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism.

Source: 
PubMed
Date Published: 
May 22, 2012
Abstract: 

Data suggest that dysregulation of carnitine metabolism may be important in nondysmorphic autism; that abnormalities of carnitine intake, loss, transport, or synthesis may be important in a larger fraction of nondysmorphic autism cases; and that the carnitine pathway may provide a novel target for therapy or prevention of autism.

Differences in White Matter Fiber Tract Development Present from 6 to 24 Months in Infants with Autism.

Source: 
American Journal of Psychiatry
Date Published: 
June 2012
Abstract: 

Research suggests that aberrant development of white matter pathways may precede the manifestation of autistic symptoms in the first year of life.

The Geometric Structure of the Brain Fiber Pathways

Source: 
Science
Date Published: 
March 30, 2012
Abstract: 

Using diffusion magnetic resonance imaging, researchers found cerebral fiber pathways formed a rectilinear three-dimensional grid and Cortico-cortical pathways formed parallel sheets of interwoven paths in four nonhuman primate species and in humans.

Autistic-like Behaviour and Cerebellar Dysfunction in Purkinje cell Tsc1 Mutant Mice.

Source: 
Nature
Date Published: 
August 30, 2012
Abstract: 

Researchers found molecular basis for a cerebellar contribution to cognitive disorders such as autism.

Developmental Trajectories of Resting EEG Power: an Endophenotype of Autism Spectrum Disorder.

Source: 
PLoS One
Date Published: 
2012
Abstract: 

Differences in the nature of the trajectories of EEG power represent important endophenotypes of ASD.

Day and nighttime excretion of 6-sulphatoxymelatonin in adolescents and young adults with autistic disorder.

Source: 
PubMed
Date Published: 
Dec 2012
Abstract: 

A deficit in melatonin production is present both at daytime and at nighttime in individuals with autism, particularly in the most severely affected individuals.

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

Source: 
Annual Review of Neuroscience
Date Published: 
2012
Abstract: 

Researchers unexpectedly found that neural complement proteins may have a roll in the elimination of connections between brain cells, potentially driving disease progression.