Autism Research

Autism-associated promoter variant in MET impacts functional and structural brain networks.

Source: 
PubMed
Date Published: 
Sept. 6, 2012
Abstract: 

Findings highlight how genetic stratification may reduce heterogeneity and help elucidate the biological basis of complex neuropsychiatric disorders such as ASD.

Atypical Brain Activation Patterns During a Face-to-Face Joint Attention Game in Adults with Autism Spectrum Disorder.

Source: 
Human Brain Mapping
Date Published: 
April 16, 2012
Abstract: 

Researchers used fMRI while participants played a joint-attention game to better understand the neural correlates of joint attention.

Mutations in BCKD-kinase Lead to a Potentially Treatable form of Autism with Epilepsy.

Source: 
Science
Date Published: 
Oct. 19, 2012
Abstract: 

Researchers identified inactivating mutations in the gene BCKDK (Branched Chain Ketoacid Dehydrogenase Kinase) in consanguineous families with autism, epilepsy, and intellectual disability.

Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism.

Source: 
PubMed
Date Published: 
March. 2013
Abstract: 

Oxidative stress and abnormal DNA methylation have been implicated in the pathophysiology of autism. This investigated the dynamics of an integrated metabolic pathway essential for cellular antioxidant and methylation capacity in children with autism.

Anxiety, sensory over-responsivity, and gastrointestinal problems in children with autism spectrum disorders

Source: 
PubMed
Date Published: 
Jan. 2013
Abstract: 

Children with autism spectrum disorders (ASD) experience high rates of anxiety, sensory processing problems, and gastrointestinal (GI) problems; however, the associations among these symptoms in children with ASD have not been previously examined. The current study examined bivariate and multivariate relations among anxiety, sensory over-responsivity, and chronic GI problems in a sample of 2,973 children with ASD enrolled in the Autism Treatment Network (ages 2-17 years, 81.6 % male).

Special Report: Connectivity

Source: 
SFARI
Date Published: 
March 25, 2013
Abstract: 

This special report from the Simons Foundation looks at neural connectivity theories of autism.

Association of Maternal Exposure to Childhood Abuse With Elevated Risk for Autism in Offspring

Source: 
JAMA Psychiatry
Date Published: 
March 20, 2013
Abstract: 

This study examined the relationship between maternal childhood abuse and autism in children in a large population-based sample. Maternal abuse was significantly associated with increased autism risk even after researchers controlled for perinatal risk factors, including gestational diabetes, smoking during pregnancy, preeclampsia, exposure to intimate partner violence and premature birth.

Changes in Prevalence of Parent-reported Autism Spectrum Disorder in School-aged U.S. Children: 2007 to 2011–2012

Source: 
CDC
Date Published: 
March 20, 2013
Abstract: 

This report presents data on the prevalence of diagnosed autism spectrum disorder (ASD) as reported by parents of school-aged children (ages 6–17 years) in 2011–2012. Results suggest 1 in 50 U.S. children is diagnosed with ASD based on parent report.

Mother's Drive Helps Research on Rare Autism-linked Mutation

Source: 
SFARI
Date Published: 
March 14, 2013
Abstract: 

A mother with two sons with autism helps advance research on neuroligin-4 mutations.

Developmental Meta-Analysis of the Functional Neural Correlates of Autism Spectrum Disorders

Source: 
Journal of the American Academy of Child and Adolescent Psychiatry
Date Published: 
December 26, 2012
Abstract: 

According to this recent meta-analysis of fMRI studies, autism-related changes in brain activity may continue to develop with age.