Repetitive Behavior

New Behavioral Test Uncovers Autism Mouse's Stubbornness

Source: 
Simons Foundation Autism Research Institute
Date Published: 
October 2, 2013
Abstract: 

Researchers have developed a new test that reveals complex repetitive behaviors in BTBR mice, a mouse strain with features resembling those of autism, according to a study published in the Journal of Neuroscience Methods. Repetitive behavior is common in autism, and usually comes in two forms: repetitive actions, such as hand flapping or rocking, and higher-order symptoms, such as an insistence on sameness, or restricted interests. This second form is difficult to produce in mice, but these researchers believe they have been able to do it.

Two Studies Isolate Specific Brain Circuits That Underlie Compulsive Behaviors Seen in Individuals with OCD and Autism

Source: 
Science
Date Published: 
June 7, 2013
Abstract: 

Two studies successfully attempted to shut down and trigger compulsive behaviors in mice by using light to target certain brain circuits. These studies helped isolate the obsessive brain circuits believed to underlie compulsive behaviors in individuals with OCD and autism.

1) http://www.ncbi.nlm.nih.gov/pubmed/23744950
2) http://www.ncbi.nlm.nih.gov/pubmed/23744948

Frequency and Pattern of Documented Diagnostic Features and the Age of Autism Identification

Source: 
Journal of the American Academy of Child & Pediatric Psychiatry
Date Published: 
February 6, 2013
Abstract: 

The age at which a child with autism is diagnosed is related to the particular suite of behavioral symptoms he or she exhibits, according to this study led by an ASF Grantee. Certain diagnostic features, including poor nonverbal communication and repetitive behaviors, were associated with earlier identification of an autism spectrum disorder. Displaying more behavioral features was also associated with earlier diagnosis.

For more information about this study, read the guest blog from the lead author here: http://autismsciencefoundation.wordpress.com/2013/04/09/identifying-asd-...

Elevated Repetitive Behaviors are Associated with Lower Diurnal Salivary Cortisol Levels in Autism Spectrum Disorder

Source: 
Biological Psychiatry
Date Published: 
March 1, 2013
Abstract: 

This pilot study examined the relationship between repetitive behaviors (RBs) and cortisol, a hormone that is released in response to stress, in individuals with ASD. Multiple salivary cortisol samples were taken over three days for 21 children with ASD with high and low levels of RBs. Children in both groups showed the same pattern of cortisol change throughout the day, but the overall cortisol levels in the high RB group were significantly lower, suggesting RBs may work to soothe and decrease stress.

Six Developmental Trajectories Characterize Children With Autism

Source: 
Pediatrics
Date Published: 
May 2012
Abstract: 

"OBJECTIVE: The goal of this study was to describe the typical longitudinal developmental trajectories of social and communication functioning in children with autism and to determine the correlates of these trajectories.
RESULTS: Six typical patterns of social, communication, and repetitive behavior functioning were identified. These trajectories displayed significant heterogeneity in developmental pathways, and children whose symptoms were least severe at first diagnosis tended to improve more rapidly than those severely affected. "

Antioxidants For Autism

Source: 
Biological Psychiatry
Date Published: 
June 1, 2012
Abstract: 

A specific antioxidant supplement containing N-Acetylcysteine, or NAC may be an effective therapy for some features of autism, according to a pilot trial from the Stanford University School of Medicine and Lucile Packard Children's Hospital that involved 31 children with the disorder.

A specific antioxidant supplement containing N-Acetylcysteine, or NAC may be an effective therapy for some features of autism, according to a pilot trial from the Stanford University School of Medicine and Lucile Packard Children's Hospital that involved 31 children with the disorder.

Agent Reduces Autism-like Behaviors in Mice

Source: 
NIMH
Date Published: 
April 26, 2012
Abstract: 

National Institutes of Health researchers have reversed behaviors in mice resembling two of the three core symptoms of autism spectrum disorders (ASD). An experimental compound, called GRN-529, increased social interactions and lessened repetitive self-grooming behavior in a strain of mice that normally display such autism-like behaviors, the researchers say.

Evidence behind autism drugs may be biased: study

Source: 
Reuters
Date Published: 
April 24, 2012
Abstract: 

Doctors' belief that certain antidepressants can help to treat repetitive behaviors in kids with autism may be based on incomplete information, according to a new review of published and unpublished research.

Training Parents Is Good Medicine for Children With Autism Behavior Problems, Study Suggests

Source: 
Science Daily
Date Published: 
February 24, 2012
Abstract: 

Children with autism spectrum disorders who also have serious behavioral problems responded better to medication combined with training for their parents than to treatment with medication alone, Yale researchers and their colleagues report in the February issue of Journal of the American Academy of Child & Adolescent Psychiatry.

Repetitive behaviors in adults with Autism Spectrum disorders significantly lessen with antidepressant treatment

Source: 
MedicalXpress
Date Published: 
December 5, 2011
Abstract: 

Restricted, repetitive behavior, such as compulsive arranging and rigid adherence to routines, is a defining symptom of autism spectrum disorders. A 12-week study showed that the antidepressant fluoxetine produced a greater decrease in repetitive behaviors and more overall improvement than placebo in adults with autism spectrum disorders.