Astroglial FMRP-Dependent Translational Down-regulation of mGluR5 Underlies Glutamate Transporter GLT1 Dysregulation in the Fragile X Mouse

Submitted by djohnson on February 15, 2013 - 14:47
Source: 
Human Molecular Genetics
Link: 
http://hmg.oxfordjournals.org/content/early/2013/02/07/hmg.ddt055.abstract
Date Published: 
February 7, 2013
Abstract: 

This paper discusses the role fragile X mental retardation protein (FMRP) plays in protein expression in astrocytes, and suggests that FMRP loss in astrocytes may contribute to the development of fragile X.